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Top2a cancer

WebTOP2A (TOP2) protein expression summary. This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcripti on. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and … Web3. aug 2012 · The TOP2A amplification is related to anthracycline-based neoadjuvant chemotherapy sensitivity, and TOP2A should be included in future studies in breast …

High expression of TOP2A gene predicted poor prognosis of ...

Web11. sep 2024 · We analyzed the expression profile of TOP2A in various human tumors using Oncomine database, and the results revealed that TOP2A expression was higher in most solid tumors including lung cancer, bladder cancer, brain cancer, breast cancer, digestive tract cancers, liver cancer and many other cancers comparing to their matched normal … body pillow afterpay https://baileylicensing.com

Alteraciones del gen TOP2A - Histopat laboratoris

Web1. okt 2010 · CÁNCER DE MAMA. El gen Topoisomerasa II-alpha (TOP2A) codifica para una enzima nuclear que actúa durante los procesos de replicación, recombinación y segregación cromosómica, alterando la topología del DNA y separando las cadenas de la doble hélice.El hecho de que sea una enzima clave en la proliferación, tanto de las células normales … Web21. aug 2024 · The aim of the present study was to determine the role of topoisomerase 1 (TOP1) and topoisomerase 2A (TOP2A) in liver cancer (LC), and to investigate the inhibitory effect of nitidine chloride (NC) on these two topoisomerases. Immunohistochemistry (IHC) staining and microarray or RNA sequencing data mining showed markedly higher … Web27. mar 2024 · Topoisomerase II alpha (TOP2A) protein has been shown to be a proliferation marker associated with tumor grade and Ki67 index. The prognostic effect … body pillow after hip surgery

TOP2A gene copy number change in breast cancer - PubMed

Category:TOP2A protein expression summary - The Human Protein Atlas

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Top2a cancer

TOP2A induces malignant character of pancreatic cancer …

Web1. máj 2024 · In addition, TOP2A could be considered as valuable prognostic biomarkers to identify prostatic patients, non-small cell lung cancer and lung cancer (Hou et al., 2024; Labbe et al., 2024; Ma et al., 2024). A study proved that autoantibody against TOP2A could identify lung cancer patients, benign lung disease from normal control (Pei et al., 2024). WebPred 1 dňom · Anthracycline plus taxane regimens are most efficacious at reducing breast cancer recurrence and death. Regimens with higher cumulative doses of anthracycline …

Top2a cancer

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Web3. aug 2012 · Anthracycline is a DNA topoisomerase 2-α (TOP2A) inhibitor and its concomitant over expression with Human Epidermal Growth Factor Receptor 2 (HER2) was investigated of being predictive for the response to anthracycline-based chemotherapies in breast cancer. 309 early and local advanced breast cancer patients were treated with … Web12. sep 2003 · To determine the frequency of genomic alterations of HER-2 and TOP2A in bladder cancer, we analyzed the subset of 1,853 tumor samples representing the first …

WebThis section contains mRNA and protein expression data from 17 different forms of human cancer, as well as correlation analysis of mRNA expression and patient survival. The … http://www.cancerindex.org/geneweb/TOP2A.htm

Web1. jan 2024 · TOP2A is an enzyme that controls the topological states of DNA. It catalyzes double-strand DNA breaking and promotes gene transcription during mitosis [3]. It has … Web11. sep 2024 · Using bioinformatic analysis, we revealed that TOP2A could be adopted as a prognostic indicator of NSCLC and it potentially regulate cancer development through co …

WebHigh expression of TOP2A in many types of tumors, such as non-small cell lung cancer, hepatocellular carcinoma, and breast cancer, has been proven to be a dependable proliferation marker and is ...

Web31. mar 2024 · Further studies showed that CDK1 that interacts with TOP2A was significantly reduced after TOP2A knockdown. We demonstrated that CX258 significantly inhibited DLD-1 CRC cell xenografts in SCID mice. In summary, we identified CX258 as a promising candidate for colorectal cancer treatment by targeting the TOP2A/Wnt/β … body pillow albedoWeb14. apr 2024 · A.C.D. is supported by grants from the American Cancer Society (129755-RSG-16-176-DDC), the National Institutes of Health/National Cancer Institute (2RO1 CA177875 and RO1 CA2558451), the Melanoma ... glenmore street redford michiganWeb21. máj 2024 · Targeting TOP2A is a promising approach in cancer therapy and some agents have been approved in clinical use, such as etoposide and teniposide 18. As an enzyme, ... glenmore reservoir calgaryWebtop2a PATHOLOGY CERVICAL CANCER BREAST CANCER CARCINOID CERVICAL CANCER COLORECTAL CANCER ENDOMETRIAL CANCER GLIOMA HEAD AND NECK CANCER … glenmore rooftop barWeb10. feb 2024 · Background: Topoisomerase IIA (TOP2A) gene encodes DNA topoisomerase enzyme and has been reported that TOP2A is broadly expressed in many types of … glenmore state highWebPatients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent. Read more. TOP2A is not prognostic in cervical cancer. Alive (n=220) glenmore state primary school rockhamptonWeb21. mar 2024 · TOP2A (DNA Topoisomerase II Alpha) is a Protein Coding gene. Diseases associated with TOP2A include Malignant Peripheral Nerve Sheath Tumor and … glenmore sailing club