WebTOP2A (TOP2) protein expression summary. This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcripti on. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and … Web3. aug 2012 · The TOP2A amplification is related to anthracycline-based neoadjuvant chemotherapy sensitivity, and TOP2A should be included in future studies in breast …
High expression of TOP2A gene predicted poor prognosis of ...
Web11. sep 2024 · We analyzed the expression profile of TOP2A in various human tumors using Oncomine database, and the results revealed that TOP2A expression was higher in most solid tumors including lung cancer, bladder cancer, brain cancer, breast cancer, digestive tract cancers, liver cancer and many other cancers comparing to their matched normal … body pillow afterpay
Alteraciones del gen TOP2A - Histopat laboratoris
Web1. okt 2010 · CÁNCER DE MAMA. El gen Topoisomerasa II-alpha (TOP2A) codifica para una enzima nuclear que actúa durante los procesos de replicación, recombinación y segregación cromosómica, alterando la topología del DNA y separando las cadenas de la doble hélice.El hecho de que sea una enzima clave en la proliferación, tanto de las células normales … Web21. aug 2024 · The aim of the present study was to determine the role of topoisomerase 1 (TOP1) and topoisomerase 2A (TOP2A) in liver cancer (LC), and to investigate the inhibitory effect of nitidine chloride (NC) on these two topoisomerases. Immunohistochemistry (IHC) staining and microarray or RNA sequencing data mining showed markedly higher … Web27. mar 2024 · Topoisomerase II alpha (TOP2A) protein has been shown to be a proliferation marker associated with tumor grade and Ki67 index. The prognostic effect … body pillow after hip surgery