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Mef2c all

Web19 nov. 2024 · MEF2C has been shown to be a critical transcription factor for neurodevelopment, whose loss-of-function mutation in humans results in MEF2C haploinsufficiency syndrome (MHS), a severe form of autism spectrum disorder (ASD)/intellectual disability (ID). Here, we use patient hiPSC-derived cerebrocortical … Web22 feb. 2016 · Previous work had shown that myocyte enhancer factor 2C (MEF2C) is indispensable for the lymphoid fate decision, yet the specific mechanism of action …

Gene - MEF2C

WebMEF2C haploinsufficiency syndrome was recently recognized as a neurodevelopmental disorder. Severe intellectual disability with inability to speak and epilepsy are universal … Web14 apr. 2024 · In this study, we identify a source of Mfge8 within human gastric antrum muscles using spatial transcriptomic analysis. We show that Mfge8 is expressed in subpopulations of Mef2c + perivascular cells within the submucosa layer of the gastric antrum. Mef2c is expressed in subpopulations of NG2 + and PDGFRB + pericytes. lapsiystävällinen kysely https://baileylicensing.com

MEF2C - an overview ScienceDirect Topics

Web1 apr. 2024 · MEF2C was the preferred candidate to study given its known function as an oncogene in lymphoid malignancies ( 35) and cooperation with MLL -rearranged AML ( 19 ). The observed MEF2C pS222 peptide was distinct from the related MEF2A, MEF2B, and MEF2D peptides (Supplementary Fig. S1C). Web27 aug. 2024 · As changes in neuronal activity may be observed across sleep-wake states, we investigated the possible role of MEF2C as a key regulator of sleep-related control of gene expression, sleep-related modulation of synaptic function and sleep-need correlated SWS-SWA buildup and resolution. Results Figure 1A Figure 1 with 3 supplements see … WebAntibodies that detect MEF2C can be used in several scientific applications, including Western Blot, Immunohistochemistry, Immunocytochemistry, Flow Cytometry and ELISA. These antibodies target MEF2C in Human, Mouse, Rat, Zebrafish and Non-human primate samples. Our MEF2C monoclonal and polyclonal antibodies are developed in Mouse … lapsiystävällinen oulu

Integrated transcript and genome analyses reveal NKX2-1 and …

Category:Q06413 - UniProt

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Mef2c all

Myocyte enhancer factor 2C in hematopoiesis and leukemia

Web19 sep. 2014 · We identified several statistically significant associations with age-related cataract (45 SNPs) as well as age at diagnosis (44 SNPs). The 45 SNPs associated with cataract at p<1×10 −5 are in several interesting genes, including ALDOB, MAP3K1, and MEF2C. All have potential biologic relationships with cataracts. Web23 mrt. 2016 · RNA was collected 48 h post-transfection. mRNA levels of HDAC4, Runx2 or MEF2C were detected with real-time PCR. * p < 0.05, compared with control miRNA mimic (ConmiR.); # p < 0.05, compared with control miRNA inhibitor (Control); (C) Western blot analysis of HDAC4 expression in human articular chondrocytes transfected with miR-365 …

Mef2c all

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Web5 sep. 2024 · A novel lncRNA gene MEF2C antisense RNA 1 ( MEF2C-AS1 ), located at 5q14.3, has been identified to be downregulated and to play tumor suppressor roles in diffuse gastric cancer (DGC), cervical cancer (CC), and BC by inhibiting cell proliferation and aggressive tumor phenotypes [ 27, 28, 29 ]. WebThe NeuroMab™ anti-MEF2C antibody detects endogenous levels of total MEF2C protein. Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to a region surrounding Met182 of human MEF2C protein. Store at -20°C. Do not aliquot the antibody.

WebAll donations and fundraising proceeds will go directly to Dr. Lipton’s Lab. His research is the only known to date that has created promising treatments. We will be able to get treatment for this rare syndrome in the future with your help. We encourage you to get involved in this hopeful project helping build a better future for our MEF2C ... Web22 feb. 2016 · MEF2C is the only isoform in the MEF2 family whose expression in blood cells is restricted to B lymphocytes [ 11 ]. Conditional knockouts at different developmental stages have been generated from mice with a floxed Mef2c exon 2, which encodes the MADS DNA-binding and dimerization domains [ 12 ].

Web30 apr. 2024 · Purpose of Review Rearrangements of the histone lysine [K]-MethylTransferase 2A gene (KMT2A) gene on chromosome 11q23, formerly known as the mixed-lineage leukemia (MLL) gene, are found in 10% and 5% of adult and children ALL cases, respectively. The most common translocated genes are AFF1 (formerly AF4), … Web17 jun. 2024 · MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 72%1592230 Mitochondrial biogenesis Idh2 Atf2 Atp5f1 Prkaa2 Creb1 Nr1d1 Nrf1 Prkag3 Tbl1xr1 Prkag1 Prkag2 Ppargc1a Ppargc1b Ppara Mef2d Chd9 Alas1 Hdac3 Esrra Crebbp Mapk14 Mapk12 Mef2c Acss2 Mapk11 Atp5b Atp5d Tbl1x Atp5g3 Atp5a1 Atp5s …

Web20 okt. 2015 · In all 751 available patient specimens, MEF2C messenger RNA (mRNA) was detectable and varied >3000-fold relative to β-glucuronidase. Patients with the highest relative MEF2C expression (4th quartile) less likely achieved a complete remission after one course of chemotherapy than the other patients (67 vs. 78 %, P = 0.005).

Web12 apr. 2011 · Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia. To identify oncogenic … lapson luu twitterWeb6 jan. 2024 · MEF2C-related epilepsy has been reported [9, 53, 82] (Table 2). Its prevalence ranges between 54% and 82% [9, 53]. The associated genetic defects include MEF2C … lapsiystävällinen ravintola tampereWeb7 jan. 2024 · For genes with an FPKM-normalized count of 0 in the control cells, if their counts in the MYOCD-MEF2C-expressing cells were 5 or higher, they were considered to be sufficiently induced by MYOCD-MEF2C. Statistics and reproducibility. All statistical data in this study were generated from at least three repetitions of independent biological ... lapstunnistaja