Webalso shown to be upregulated in some cancers, mainly in response to the increased burden of protein degradation, indicating that VCP inhibition could be a promising therapeutic … Web1 okt. 2024 · HRD1 (3-hydroxy-3-methylglutaryl reductase degradation), an ER associated degradation (ERAD)-associated E3 ubiquitin Ligase, which is also called synoviolin, …

ER-associated ubiquitin ligase HRD1 programs liver metabolism by ...

Web24 aug. 2024 · Hepatocellular carcinoma (HCC) is an aggressive liver tumor that occurs due to chronic liver disease, and it has a high mortality rate and limited treatment … Web2 feb. 2024 · E3 ubiquitin ligase HRD1 (HMG-CoA reductase degradation protein 1, alias synoviolin with SYVN1 as the official gene symbol) was found downregulated and acting … cox community login

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Web1 apr. 2024 · DOI: 10.1016/j.ajpath.2024.03.009 Corpus ID: 258020499; The dynamic role of endoplasmic reticulum stress in chronic liver disease. @article{Jackson2024TheDR, title={The dynamic role of endoplasmic reticulum stress in chronic liver disease.}, author={Kaitlyn G. Jackson and Grayson W. Way and Jing Zeng and Marissa K. Lipp … Web31 jan. 2024 · The endoplasmic reticulum is a central player in liver pathophysiology. Chronic injury to the ER through increased lipid content, alcohol metabolism, or … Web2 nov. 2024 · Expression of Sel1L-Hrd1 ERAD in the liver is responsive to physiological signals As the liver plays a vital role in nutrient metabolism, we speculate that the levels of Sel1L-Hrd1 ERAD in the liver may fluctuate in response to metabolic signals during growth and fasting-feeding. disney pixar cars scooter