WebImportant for the overall degradation of proteins in lysosomes. The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase … WebThe cytoskeletal protein talin, an actin- and β-integrin tail-binding protein, plays an important role in cell migration by promoting integrin activation and focal adhesion formation. Here, we show that talin is a substrate for cathepsin H (CtsH), a lysosomal cysteine protease with a strong aminopeptidase activity. Purified active CtsH sequentially cleaved …
Pharos : Target Details - CTSH - National Institutes of Health
WebJan 30, 2024 · Another type 1 diabetes susceptibility gene, Cathepsin H (CTSH) [36, 37], is a lysosomal cysteine protease that is crucial for lysosomal protein degradation. Importantly, the CTSH susceptibility allele is associated with faster disease progression in newly diagnosed diabetes and reduced beta cell function in healthy humans . WebCTSH. The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide … cu factory built insurance agency llc
NM_004390.5(CTSH):c.785A>G (p.Tyr262Cys) AND Inborn genetic …
WebFurthermore, the up-regulation of the CTSH protein in HepG2 cells after IR gave us a definitive answer to explain the phenomenon that the HepG2 cell was more resistant to radiation than the MHCC97H cell, in which the CTSH expression did not increase as significantly as in the HepG2 cell (Figure 2 e,i,j). From this perspective, we found a novel ... WebConsistent with extensive gene/protein characterization data. Consistent with extensive gene/protein characterization data. RNA consistency i High consistency between antibody staining and RNA expression data. High consistency between antibody staining and RNA expression data. ... CTSH-201. CTSH-207. CTSH-218. CTSH-232. CTSH-233. CTSH … WebCathepsin H (CTSH) is a type 1 diabetes (T1D) risk gene; large-scale genetic and epidemiological studies found that T1D genetic risk correlates with high CTSH … eastern bank in ma