WebNov 17, 2024 · Methods that use summary statistics from genome-wide association studies (GWAS) to investigate genetic overlap across phenotypes have become a fundamental statistical tool across many … WebApr 2, 2024 · This work develops a statistical method for cross-population fine-mapping (XMAP) by leveraging genetic diversity and accounting for confounding bias that can achieve greater statistical power, better control of false positive rate, and substantially higher computational efficiency for identifying multiple causal signals, compared to existing …
Adrien Badré Ph.D. - Graduate Assistant - University of Oklahoma
WebJul 6, 2024 · Additional genetic methods using GWAS summary statistics, including cross-trait meta-analysis 19 and transcriptome-wide association study (TWAS) 20, may be used to identify specific shared genetic ... We would like to show you a description here but the site won’t allow us. WebJan 20, 2024 · GWAS has identified genetic variation for many complex traits, but studies have shown that many detected loci can be associated with multiple traits at the same time. This phenomenon is called cross-phenotype (CP) association, or simply put, pleiotropy ( Solovieff et al., 2013 ). bolt of gransax spear
precimed/mixer: Causal Mixture Model for GWAS …
WebSep 26, 2024 · Genome-wide association studies (GWAS) deliver effect size estimates of a given trait for millions of Single Nucleotide Polymorphisms (SNPs). Powerful tools already exist using these … WebNational Center for Biotechnology Information WebCross-trait LD Score regression (Bulik-Sullivan et al. 2015b) is a method for estimating genetic correlations using GWAS summary statistics. We have extended stratified LD score regression to gene expression phenotypes ( Liu et al. 2024 ). bolt of green denim cloth