WebAug 18, 2011 · Clonality, genetic diversity and support for the diversifying selection hypothesis in natural populations of a flower-living yeast C. M. HERRERA, M. I. POZO, … WebTo evaluate the clonality of T cell repertoire, we utilized the Simpson Clonality Index, calculated as the square root of Simpson diversity metric. Simpson Clonality is generally recommended over Shannon Clonality (another commonly used diversity score) because it is less sensitive to differences in total number of sequences.
T cell clonality assessment: past, present and future
WebJan 9, 2024 · We found measurements of Shannon diversity index, clonality, and clonal overlap to be significantly correlated between the two platforms (Figures 1A–C, Pearson's correlation = 0.88; p = 0.007). We also note a trend toward higher clonality values in the Oncomine dataset ( p = 0.04, Wilcoxon signed sum test, Supplemental Figure 1A ... WebHere we present the common technologies of bulk and single-cell sequencing of T-cell receptors (TCRs), discuss current knowledge regarding computational tools … parkchester map
Immune awakening revealed by peripheral T cell dynamics after ... - Nature
Webclone. 1. Biology a group of organisms or cells of the same genetic constitution that are descended from a common ancestor by asexual reproduction, as by cuttings, grafting, … WebMay 28, 2015 · 4) Repertoire diversity and gene usage analysis: For the analysis of the V and J gene usage, the package employs Shannon entropy measure, Jensen-Shannon divergence and Principal Component Analysis. To evaluate the repertoire diversity, the effective number of types (“true diversity”), Gini and Gini-Simpson indices, inverse … WebTest Usage. T cell lymphoproliferative disorders are frequently associated with clonal rearrangements of the T cell receptor gamma (TRG) and/or beta (TRB) loci. Evaluation of the TRB locus may occasionally demonstrate clonal rearrangements not detected by TRG testing, and vice versa. This test employs multiplexed PCR primers to detect gene ... time tracking notebook