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Circhif1a

WebMini-Circuits. Manufacturer Product Number. PHA-1+. Description. IC RF AMP CATV 50MHZ-6GHZ SOT89. Manufacturer Standard Lead Time. 10 Weeks. Detailed … WebcircHIF1A-miRNA-149-5p Interaction with NFIB: Promotion of cell proliferation and metastasis: 0.897: Chen 2024 : Table 2. Summary of the prognostic and predictive role of blood circulating ncRNAs for TNBC (AUC—area under the ROC, CR—complete response, HR—hazard ratio, OR—odds ratio, OS—overall survival, PD—progressive disease, PR ...

Hypoxia-responsive circRNAs: A novel but important participant

WebJun 12, 2024 · Europe PMC is an archive of life sciences journal literature. WebMay 10, 2024 · So, circHIF1A could be a novel biomarker for the diagnosis and therapeutic target of TNBC . Epithelial-mesenchymal transformation (EMT) is a fundamental level in TNBC metastasis. Epithelial-mesenchymal transformation (EMT) is a fundamental level in TNBC metastasis. r00 nih grant https://baileylicensing.com

HIF1A hypoxia inducible factor 1 subunit alpha [ (human)]

WebRegulation of HIF-1α stability can also be mediated by an oxygen-independent pathway. In the cytoplasm, HIF-1α is bound to heat-shock protein 90 (Hsp90), leading to enhanced … WebJun 3, 2024 · Posttranscriptional tRNA modifications are essential for proper gene expression, and defects in the enzymes that perform tRNA modifications ar ... WebApr 19, 2024 · A recent study revealed that circHIF1A (hsa_circ_0004623) promoted cancer cell proliferation and metastasis in triple-negative breast cancer (TNBC). Mechanistically, circHIF1A regulates the expression and translocation of NFIB through post-transcriptional and post-translational modifications, resulting in activation of the AKT/STAT3 signaling ... donfeijao

Identification and characteristics of circHIF1A in breast cancer …

Category:Emerging Roles of CircRNAs in Tumor Microenvironment

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Circhif1a

Carcinoma-associated fibroblasts derived exosomes modulate …

WebAug 29, 2024 · We previously reported that circHIF1A could facilitate TNBC proliferation and metastasis by increasing the expression level of NFIB . However, the functions and underlying mechanisms of circRNAs in regulating chemoresistance of TNBC are largely unknown. Therefore, identifying circRNAs that possess regulatory roles in … WebApr 15, 2024 · CircHIF1A promoted TNBC progression both in vitro and in vivo A (left) Cluster heat map showed the differentially expressed genes in MDA-MB-231 cells with circHIF1A overexpression and control cells.

Circhif1a

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WebJun 14, 2024 · [Cell Death Discovery] Through investigating cellular functions including cell proliferation and stem cell features, it was demonstrated that hypoxic cancer-associated … WebJul 28, 2024 · In another study, exosomal circHIF1A significantly promoted triple negative breast cancer growth. An exosomal circHIF1A/NFIB/FUS feedback loop was validated by Chen et al., as exosomal circHIF1A modulated the expression and translocation of NFIB through post-transcriptional and post-translational modification.

WebHIF1A. Hypoxia-inducible factor 1-alpha, also known as HIF-1-alpha, is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 ( HIF-1) that is encoded by the HIF1A gene. [5] [6] [7] The Nobel Prize in … WebJan 11, 2024 · In support of circHIF1A as a biomarker and target molecule for breast cancer therapy, Zhan and colleagues identified this molecule in a screening of circRNA present in exosomes from hypoxic CAFs in breast cancer . circHIF1A from hypoxic CAFs-derived exosomes proved to be an important player in conferring stem cell properties to breast …

WebChen, T., Wang, X., Li, C., Zhang, H., Liu, Y., Han, D., … Yang, Q. (2024). CircHIF1A regulated by FUS accelerates triple-negative breast cancer progression by ... WebDec 1, 2024 · The circHIF1A can act as a sponge for miR-580-5p and decrease the level of miR-580-5p, which was shown to target the CD44 molecule (CD44) mRNA and decrease the expression of CD44. In this way, the up-regulated circHIF1A from CAFs-derived exosome in hypoxia can boost the expression of CD44 indirectly, and then enhance the …

WebK The relative RNA levels of circHIF1A and linear HIF1A were analyzed by qRT-PCR assay after treatment with Actinomycin D in MDA-MB-231 cells. L The relative RNA levels of circHIF1A, linear HIF1A ...

WebJun 12, 2024 · CircHIF1A may act as a target molecule of breast cancer therapy. Hypoxia is a common phenomenon in solid tumors. The roles of exosomes from hypoxic breast … r0127 rnase dnase rna and dna awayWebMar 2, 2024 · CircHIF1A regulated by FUS accelerates triple-negative breast cancer progression by modulating NFIB expression and translocation 13 March 2024 Tong Chen, Xiaolong Wang, … doneztebeko udala telefonoaWebcircHIF1A was selectively upregulated in hypoxic breast cancer exosomes specifically.25 Additionally, circHIF1A counteracting miR-580-5p-mediated inhibition on CD44 via sponging miR-580-5p was found to be the mechanism via which CAFs modulated the stemness of cancer cells. The discovery may establish circHIF1A don fabio zanin